PO-01-020 PERI-OPERATIVE AMIODARONE PROPHYLAXIS IN CARDIOVASCULAR SURGERY: IMPACTS ON POST-OPERATIVE LENGTH OF STAY ACCORDING TO PROCEDURE TYPES

Post-operative Atrial Fibrillation (POAF), occurring in nearly 20-50 percent of cardiovascular surgery (CVS) patients, is associated with prolonged hospitalization and excess costs care. Peri-operative Amiodarone prophylaxis has been an effective strategy to reduce the incidence POAF. A retrospective evaluation impact on post-operative length hospital (LOS) stay, according CVS procedure types. Hospitalization information was available for 2704 consecutive patients at a single tertiary care centre (2013-2016). included standalone, or combined procedures that involved: valvular heart (VHS), coronary artery bypass graft (CABG), other miscellaneous (e.g. ascending aorta replacement, endarterectomy). Hierarchical linear regression used evaluate LOS, adjusted demographic clinical characteristics. Among there were 866 (32.0%) cases significantly longer POAF (+2.78 days, p<0.001). LOS 1.62 days shorter who received (p=0.007). Within all operative categories, receiving amiodarone prophylaxis, though statistical significance only observed VHS (including + other) CABG Specifically, among: had but not (8.26 versus 9.45 p= 0.29), (7.62 11.02 p<0.001), undergoing (9.36 vs. 12.41 p<0.03), (13.54 15.09 0.74). After adjusting demographic-clinical covariates hierarchical multiple regression, remained independent predictor (b= -2.3 [-3.7, -0.93], 0.001). Other predictors included: left atrial diameter >40 mm 1.7 [0.90, 2.85], p< 0.001), female sex 1.4 [0.56, 2.19], history failure 2.1 [0.94, 3.30], involving [0.15, 2.67], 0.03), 5.1 [2.51, 7.72], independently following CVS.